Aggies Innovate Alternative Treatment for Antibiotic-Resistant UTIs Using Beneficial E. Coli

A Unique Solution to a Common Problem: Aggies Tackle Antibiotic-Resistant UTIs

College Station, Texas

In the heart of Aggieland, an exciting research project is underway, aiming to change the way we combat a pesky and often painful issue: urinary tract infections (UTIs). It’s a problem affecting more than 150 million people globally each year, and while most UTIs are easily treatable with antibiotics, some individuals struggle to find relief due to antibiotic resistance. This is where Texas A&M University comes into play, harnessing the power of a *friendly* form of E. coli to tackle the issue head-on.

The journey began in 2021 at the Subash Lab in the Department of Veterinary Pathobiology. Dr. Saguru Subash, the principal investigator of this innovative project, teamed up with Dr. Taylor Ware from biomedical engineering and joined forces with Dr. Phillippe Zimmun, a clinical urologist from UT Southwestern, to gain valuable clinical insights. Together, they’re exploring a strain of E. coli that offers promise as a natural combatant against recurring UTIs.

Understanding UTIs and Their Challenges

UTIs are the bane of many, causing discomfort and sometimes serious health issues if left untreated. While antibiotics usually do the trick, a growing number of people are discovering that these medications simply aren’t effective for them anymore. Dr. Subash pointed out, “Antibiotics work for many, but they’re not a long-term solution for everyone,” prompting the need for alternative methods.

What might surprise you is that the notorious E. coli has both good and bad guys in its ranks. The harmful strains are often responsible for UTIs, but the research team is focusing on a *beneficial strain* that actually helps combat these infections. “Typically, around 75% of UTIs are caused by E. coli,” says Subash. “But we’re exploring how these *helpful* microbes can work against their *harmful* cousins.”

The Power of Beneficial Bacteria

The beneficial strain, known as the asymptomatic bacteriuria strain or ABU, was discovered around 50 years ago in Sweden, and it’s already used in preventative measures across Europe. Iris George, a graduate student working alongside Dr. Subash, is digging deep into the mechanics of how ABU wins the battle against pathogens. She explains, “Once we understand how this strain competes, we can explore innovative ways to tackle UTIs.”

The research has uncovered that ABU competes by *starving* harmful bacteria of essential nutrients. However, there’s a challenge: the strain doesn’t easily colonize in humans, meaning it needs to be strategically delivered right where it’s needed— in the bladder. “Getting this bacteria to thrive there remains a challenge, so we are developing hydrogels to slowly release the beneficial E. coli, maximizing its effect,” Subash elaborated.

Pioneering New Treatments

The hydrogels are currently being tested in a mouse model, with hopes of translating this research into human applications. But this is just the beginning. As Subash hopes, “In the best case scenario, we might see these treatments becoming available in five to seven years.” Imagine a future where UTIs can be treated with a natural solution sourced from our very own body.

Hope on the Horizon

For now, the research is still in its early stages, but the team is optimistic about the potential impact of their findings. If successful, this new approach could revolutionize how we think about antibiotics and open the door to treatments that incorporate the good bacteria living in us. It’s a friendly solution to a widespread problem — one that showcases the power of innovation and collaboration.

This captivating journey at Texas A&M reflects not just the spirit of striving for answers but also the commitment to enhancing lives through science. Community members and prospective researchers alike can feel the excitement in the air as they look forward to what these dedicated *Aggies* will accomplish next!